Medicinal Food Engineering Lab

Olawuyi IF†, Heo E†, Jeong M, Kim JH, Park JJ, Chae J, Gwon S, Lee SD, Kim H, Ojulari OV, Song YB, Lee BH, Gu BB, Kim SR, Lee JH, Lee W, Hwang JS, Nam JO, Hahn D,*, and Byun S*. Acidic polysaccharide from the edible insect Protaetia brevitarsis seulensis activates antiviral immunity to suppress norovirus infection. Carbohydrate Polymers. Volume 347, 1 January 2025, 122587 (†Co-first authors)
 

Cho YR, Han EJ, Heo E, Jayasinghe AMK, Won J, Lee S, Kim T, Kim SK, Lim S, Woo SO, Han G, Kang W, Ahn G*, Byun S*. Propolis suppresses atopic dermatitis through targeting the MKK4 pathway. Biofactors. 2024 Aug 20
 

Kim DH†, Lee S†, Ahn J†, Kim JH, Lee E*, Lee I*, Byun S*. Transcriptomic and metabolomic analysis unveils nanoplastic-induced gut barrier dysfunction via STAT1/6 and ERK pathways. Environmental Research. Volume 249, 15 May 2024, 118437 (†Co-first authors)
 

Woo MJ, Choi J, Kang HY, Jang S, Kim MJ, Kim S, Byun S*, Jung SK*. In Vitro and In Vivo Models for the Development of Hair Growth Materials By Regulating the β-Catenin Signaling Pathways. J Med Food. 2024 May;27(5):449-459. (*Co-corresponding authors)
 

Sung J, Cheong Y, Kim YS, Ahn J, Sohn MH, Byun S*, Seong BL*. Harnessing Pentameric Scaffold of Cholera Toxin B (CTB) for Design of Subvirion Recombinant Dengue Virus Vaccine. Vaccines (Basel). 2024 Jan 17;12(1):92 (*Co-corresponding authors)
 

Lee DS†, Kang JI†, Jeong M†, Byun S*, Park KM* . Engineered 3D tumor microenvironment recapitulating stiffness of lung tissue to explore drug resistance of lung carcinoma. Journal of Industrial and Engineering Chemistry. 2023. (*Co-corresponding authors) (†Co-first authors)
 

Son JE†, Jo JY†, Kim S, Park MJ, Lee Y, Park SS, Park SY, Jung SM, Jung SK, Kim JY, Byun S. Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling.
Nutrients. 2023 Aug 18;15(16):3630. (†Co-first authors)
 

Cho YR, Jo KA, Park S, Choi J, Kim G, Kim TY, Lee S, Lee DH, Kim SK, Lee D, Lee S, Lim S, Woo SO, Byun S*, Kim JY*.Combination of UHPLC-MS/MS with context-specific network and cheminformatic approaches for identifying bioactivities and active components of propolis. Food Research International. October 2023. Volume 172,113134 (*Co-corresponding authors)
 

Kim KJ, Park SY, Kim JT, Lee HJ, Jung SK, Kim YJ, Lee CH, Byun S, Kim JY. In vitro and in vivo postprandial hypoglycemic effects and comprehensive metabolite profiling of Dangjo chili pepper (Capsicum annuum L. cv. Dangjo). Food Bioscience. 2023 Feb; Volume 51.102180
 

Seo JW, Jo S, Jung YS, Mijan MA, Cha J, Hong S, Byun S*, Lim TG*. Rosa gallica and its active compound, cyanidin-3,5-O-diglucoside, improve skin hydration via the GLK signaling pathway. Biofactors. 2022 Dec 27. (*Co-corresponding authors)
 

Kim DH, Jeong M, Kim JH, Son JE, Lee JY, Park S, Lee J, Kim M, Oh JW, Park MS, and Byun S. Lactobacillus salivarius HHuMin-U activates innate immune defense against norovirus infection through TBK1-IRF3 and NF-κB signaling pathways. Research. 2022 Dec; Vol 2022
 

Lee BS†, Cho YR†, Jeong M, Jang YS, Kim JC, Byun S*, Kim KH*. Anti-Atopic Dermatitis Activity of Cornus walteri and Identification of the Bioactive Compounds. Applied Sciences. 2022, 12(17), 8857 (*Co-corresponding authors) (†Co-first authors)
 

Kim JH, Jeong M, Doo EH, Koo YT, Lee SJ, Jang JW, Park JHY, Huh CS, Byun S*, Lee KW*. Glycine max Fermented by a Novel Probiotic, Bifidobacterium animalis subsp. lactis LDTM 8102, Increases Immuno-Modulatory Function. J Microbiol Biotechnol. 2022 Sep 28;32(9):1146-1153 (*Co-corresponding authors)
 

Kim DH†, Kim JH†, Kim DH, Jo JY, Byun S. Functional foods with antiviral activity. Food Sci Biotechnol. 2022 Apr 13:1-12. (†Co-first authors)
 

Jo S†, Samarpita S†, Lee JS, Lee YJ, Son JE, Jeong M, Kim JH, Hong S, Yoo SA, Kim WU, Rasool M, and Byun S. 8-Shogaol Inhibits Rheumatoid Arthritis through Targeting TAK1. Pharmacological Research. Volume 178, April 2022, 106176
 

Kim JH†, Kim DH†, Jo S, Cho MJ, Cho YR, Lee YJ, Byun S. Immunomodulatory functional foods and their molecular mechanisms. Experimental & Molecular Medicine. 2022 Jan;54(1):1-11. (†Co-first authors)
 

Jang YJ and Byun S. Molecular targets of exercise mimetics and their natural activators. BMB Reports. 2021 Dec;54(12):581-591.
 

Kim M, Cheong Y, Lee J, Lim J, Byun S*, Jang YH* and Seong BL*. A Host-Restricted Self-Attenuated Influenza Virus Provides Broad Pan-Influenza A Protection in a Mouse Model. Frontiers in Immunology. 02 December 2021. (*Co-corresponding authors)
 

Cheong Y, Kim M, Ahn J, Oh H, Lim J, Chae W, Yang SW, Kim MS, Yu JE, Byun S*, Jang YH* and Seong BL*. Epigallocatechin-3-Gallate as a Novel Vaccine Adjuvant. Frontiers in Immunology. 12 November 2021. (*Co-corresponding authors)
 

Jo S, Jung YS, Cho YR, Seo JW, Lim WC, Nam TG, Lim TG, Byun S. Oral Administration of Rosa gallica Prevents UVB−Induced Skin Aging through Targeting the c-Raf Signaling Axis. Antioxidants. 2021,10(11), 1663.
 

Kim DH, Auh JH, Oh J, Hong S, Choi S, Shin EJ, Woo SO, Lim TG, Byun S. Propolis Suppresses UV-Induced Photoaging in Human Skin through Directly Targeting Phosphoinositide 3-Kinase. Nutrients. 2020 12(12), 3790.
 

Shin SH†, Lee JS†, Zhang JM†, Choi S, Boskovic ZV, Zhao R, Song M, Wang R, Tian J, Lee MH, Kim JH, Jeong M, Lee JH, Petukhov M, Lee SW, Kim SG, Zou L, Byun S. Synthetic Lethality by Targeting the RUVBL1/2-TTT Complex in mTORC1-Hyperactive Cancer Cells. Science Advances. 2020 Jul 31:Vol. 6, no. 31, eaay9131 (†Co-first authors)
 

Jeong M, Kim JH, Lee JS, Kang SD, Shim S, Jung MY, Yang H, Byun S*, Lee KW*. Heat-killed Lactobacillus brevis enhances phagocytic activity and generates immune-stimulatory effects through activating the TAK1 pathway. J Microbiol Biotechnol. 2020 Jun 19. (*Co-corresponding authors)
 

Kim JG, Kim MJ, Lee JS, Sydara K, Lee S, Byun S, Jung SK. Smilax guianensis Vitman Extract Prevents LPS-Induced Inflammation by Inhibiting the NF-κB Pathway in RAW 264.7 Cells. J Microbiol Biotechnol. 2020 Jun 28;30(6):822-829. 
 

Shin EJ, Jo S, Choi S, Cho CW, Lim WC, Hong HD, Lim TG, Jang YJ, Jang M, Byun S*, Rhee Y*. Red Ginseng Improves Exercise Endurance by Promoting Mitochondrial Biogenesis and Myoblast Differentiation. Molecules. 2020 Feb 16;25(4). pii: E865. (*Co-corresponding authors)
 

Shin EJ, Lee JS, Hong S, Lim TG, Byun S. Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin. Int J Mol Sci. 2019 Oct 23; 20(21).
 

Lee JS, Kim B, Kim JH, Jeong M, Lim S, Byun S. Effect of Differential Thermal Drying Conditions on the Immunomodulatory Function of Ginger. J Microbiol Biotechnol. 2019 Jul 9. doi: 10.4014/jmb.1905.05063
 

Kim JH+, Doo EH+, Jeong M+, Kim S, Lee YY, Yang J, Lee JS, Kim JH, Lee KW, Huh CS, Byun S. Enhancing immunomodulatory function of red ginseng through fermentation using Bifidobacterium animalis subsp. lactis LT 19-2. Nutrients. 2019 Jun 28; 11(7) (+Co-first authors)
 

Lim S+, Choi S+, Lee P+, Kim H, Lee D, Byun S. Non-enzymatic softening of Calendula officinalis L. petals and its anti-skin aging effect for food materialization. Korean J. Food Sci. Technol. 2019;51:243−247 (+Co-first authors)
 

Shin EJ+, Jo S+, Choi HK, Choi S, Byun S*, Lim TG*. Caffeic Acid Phenethyl Ester Inhibits UV-Induced MMP-1 Expression by Targeting Histone Acetyltransferases in Human Skin. Int J Mol Sci. 2019 Jun 22;20(12). pii: E3055. doi: 10.3390/ijms20123055 (*Co-corresponding authors) (+Co-first authors)
 

Jeong M+, Kim JH+, Yang H, Kang SD, Song S, Lee D, Lee JS, Park JHY, Byun S*, Lee KW*. Heat-killed Lactobacillus plantarum KCTC 13314BP enhances phagocytic activity and immunomodulatory effects via activation of MAPK and STAT3 pathways. J Microbiol Biotechnol. 2019 Jun 18. (*Co-corresponding authors) (+Co-first authors)
 

Lee JS+, Kim YA+, Jang YJ, Oh Y, Byun S. Dihydrocapsaicin Inhibits Epithelial Cell Transformation through Targeting Amino Acid Signaling and c-Fos Expression. Nutrients. 2019 Jun 4;11(6). pii: E1269. (+Co-first authors)
 

Jang YJ+, Kim JH+, Byun S. Modulation of Autophagy for Controlling Immunity. Cells. 2019 Feb 9;8(2). pii: E138. doi: 10.3390/cells8020138 (+Co-first authors)
 

Lee SJ+, Lee JS+, Lee EJ, Lim TG, Byun S. The ginsenoside metabolite compound K inhibits hormone-independent breast cancer through downregulation of cyclin D1. Journal of Functional Foods. 2018 July 46: 159-166. (+Co-first authors)
 

Farrand L, Byun S. Induction of Synthetic Lethality by Natural Compounds Targeting Cancer Signaling. Curr Pharm Des. 2017 Nov 16;23(29):4311-4320
 

Byun S, Lee E, Lee KW. Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer. Int J Mol Sci. 2017 Sep 12;18(9). pii: E1959. doi: 10.3390/ijms18091959
 

Shin SH, Lee, SR, Lee E, Kim KH, Byun S. Caffeic acid phenethyl ester from the twigs of Cinnamomum cassia inhibits malignant cell transformation by inducing c-Fos degradation. Journal of Natural Products. 2017 Jul 28;80(7):2124-2130.
 

Bae SY, Byun S, Bae SH, Min DS, Woo HA, Lee K. TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway. Autophagy. 2017 May 4;13(5):820-833
 

Hwang SY, Deng X, Byun S, Lee C, Lee SJ, Suh H, Zhang J, Kang Q, Zhang T, Westover KD, Mandinova A, Lee SW. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. Cell Reports. 2016 Jun 28;16(1):28-36.
 

Byun S, Shin SH, Park J, Lim S, Lee E, Lee C, Sung D, Farrand L, Lee SR, Kim KH, Dong Z, Lee SW, Lee KW. Sulforaphene suppresses growth of colon cancer-derived tumors via induction of glutathione depletion and microtubule depolymerization. Molecular Nutrition & Food Research. 2016 May;60(5):1068-78.
 

Byun S, Lee E, Jang YJ, Kim Y, Lee KW. The NADPH oxidase inhibitor apocynin inhibits UVB-induced skin carcinogenesis. Experimental Dermatology. 2016 Jun;25(6):489-91. doi: 10.1111/exd.12989
 

Byun S, Namba T, Lee SW. Losing p53 loosens up ER-stress. Aging (Albany NY). 2015 Nov;7(11):895-6
 

Byun S, Shin SH, Lee E, Lee J, Lee SY, Farrand L, Jung SK, Cho YY, Um SJ, Sin HS, Kwon YJ, Zhang C, Tsang BK, Bode AM, Lee HJ, Lee KW, Dong Z. The retinoic acid derivative, ABPN, inhibits pancreatic cancer through induction of Nrdp1. Carcinogenesis. 2015 Dec;36(12):1580-9.
 

Byun S, Lim S, Mun JY, Kim KH, Ramadhar TR, Farrand L, Shin SH, Thimmegowda NR, Lee HJ, Frank DA, Clardy J, Lee SW, Lee KW. Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways. J Biol Chem. 2015 Sep 25;290(39):23553-62
 

Hiraki M, Hwang SY, Cao S, Ramadhar TR, Byun S, Yoon KW, Lee JH, Chu K, Gurkar AU, Kolev V, Zhang J, Namba T, Murphy ME, Newman DJ, Mandinova A, Clardy J, Lee SW. Small molecule reactivation of mutant p53 to wt-like p53 through the p53-Hsp40 regulatory axis. Chem Biol. 2015 Sep 17;22(9):1206-16.
 

Namba T, Chu K, Kodamar A, Byun S, Yoon KW, Hiraki M, Mandinova A, Lee SW. Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway. Oncotarget. 2015 Aug 21;6(24):19990-20001
 

Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science. 2015 Jul 31;349(6247):126166
 

Farrand L, Kim JY, Byun S, Im-aram A, Lee J, Suh JY, Lee KW, Lee HJ, Tsang BK. The diarylheptanoid hirsutenone sensitizes chemoresistant ovarian cancer cells to cisplatin via modulation of apoptosis-inducing factor and X-linked inhibitor of apoptosis. J Biol Chem. 2014 Jan 17;289(3):1723-31
 

Jung SK, Kim JE, Lee SY, Lee MH, Byun S, Kim YA, Lim TG, Reddy K, Huang Z, Bode AM, Lee HJ, Lee KW, Dong Z. The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer. Carcinogenesis. 2014 Jan;35(1):123-30.
 

Song NR, Lee E, Byun S, Kim JE, Mottamal M, Park JH, Lim SS, Bode AM, Lee HJ, Lee KW, Dong Z. Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Cancer Prev Res (Phila). 2013 Dec;6(12):1293-303. 
 

Namba T, Tian F, Chu K, Hwang SY, Yoon KW, Byun S, Hiraki M, Mandinova A, Lee SW. CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress. Cell Reports. 2013 Oct 31;5(2):331-9
 

Kim HY, Jung SK, Byun S, Son JE, Oh MH, Lee J, Kang MJ, Heo YS, Lee KW, Lee HJ. Raf and PI3K are the molecular targets for the anti-metastatic effect of luteolin. Phytother Res. 2013 Oct;27(10):1481-8.
 

Lee E, Son JE, Byun S, Lee SJ, Kim YA, Liu K, Kim J, Lim SS, Park JH, Dong Z, Lee KW, Lee HJ. CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):12-20.
 

Farrand L, Byun S, Kim JY, Im-Aram A, Lee J, Lim S, Lee KW, Suh JY, Lee HJ, Tsang BK. Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. J Biol Chem. 2013 Aug 16;288(33):23740-50.
 

Byun S, Lee SY, Lee J, Jeong CH, Farrand L, Lim S, Reddy K, Kim JY, Lee MH, Lee HJ, Bode AM, Won Lee K, Dong Z. USP8 is a novel target for overcoming gefitinib resistance in lung cancer. Clinical Cancer Research. 2013 Jul 15;19(14):3894-904.
 

Lim SH, Jung SK, Byun S, Lee EJ, Hwang JA, Seo SG, Kim YA, Yu JG, Lee KW, Lee HJ. Luteolin suppresses UVB-induced photoageing by targeting JNK1 and p90 RSK2. J Cell Mol Med. 2013 May;17(5):672-80. 
 

Cho YY, Kim DJ, Lee HS, Jeong CH, Cho EJ, Kim MO, Byun S, Lee KY, Yao K, Carper A, Langfald A, Bode AM, Dong Z. Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells. PLoS One. 2013 Feb 25;8(2):e57172.
 

Byun S, Park J, Lee E, Lim S, Yu JG, Lee SJ, Chen H, Dong Z, Lee KW, Lee HJ. Src kinase is a direct target of apigenin against UVB-induced skin inflammation. Carcinogenesis. 2013 Feb;34(2):397-405.
 

Baek S, Kang NJ, Popowicz GM, Arciniega M, Jung SK, Byun S, Song NR, Heo YS, Kim BY, Lee HJ, Holak TA, Augustin M, Bode AM, Huber R, Dong Z, Lee KW. Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. J Mol Biol. 2013 Jan 23;425(2):411-23.
 

Ali AY, Farrand L, Kim JY, Byun S, Suh JY, Lee HJ, Tsang BK. Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum. Ann N Y Acad Sci. 2012 Oct;1271:58-67.
 

Jung SK, Lim TG, Kim JE, Byun S, Kim GW, Choi JN, Lee CH, Kim BY, Lee KW, Lee HJ. Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus. Food Chemistry. 2012 Feb;130(4): 915-20
 

Jang YJ, Kim J, Shim J, Kim J, Byun S, Oak MH, Lee KW, Lee HJ. Kaempferol attenuates 4-hydroxynonenal-induced apoptosis in PC12 cells by directly inhibiting NADPH oxidase. J Pharmacol Exp Ther. 2011 Jun;337(3):747-54.
 

Lee DE, Lee KW, Byun S, Jung SK, Song N, Lim SH, Heo YS, Kim JE, Kang NJ, Kim BY, Bowden GT, Bode AM, Lee HJ, Dong Z. 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. J Biol Chem. 2011 Apr 22;286(16):14246-56.
 

Hwang MK, Bode AM, Byun S, Song NR, Lee HJ, Lee KW, Dong Z. Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1. (2010) Cancer Research. 2010 Sep 1;70(17):6859-69.
 

Lee KM*, Lee KW*, Byun S*, Jung SK, Seo SK, Heo YS, Bode AM, Lee HJ, Dong Z. 5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer. Cancer Prev Res (Phila). 2010 Apr;3(4):454-65. (*: co-first authors)
 

Byun S, Lee KW, Jung SK, Lee EJ, Hwang MK, Lim SH, Bode AM, Lee HJ, Dong Z. Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer. Cancer Research. 2010 Mar 15;70(6):2415-23.
 

Jung SK, Lee KW, Kim HY, Oh MH, Byun S, Lim SH, Heo YS, Kang NJ, Bode AM, Dong Z, Lee HJ. Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf. Biochem Pharmacol. 2010 May 15;79(10):1455-61.
 

Jung SK, Lee KW, Byun S, Lee EJ, Kim JE, Bode AM, Dong Z, Lee HJ. Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo. Carcinogenesis. 2010 May;31(5):911-7.
 

Choi KH, Kim JE, Song NR, Son JE, Hwang MK, Byun S, Kim JH, Lee KW, Lee HJ. Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells. Cardiovascular Research. 2010 Mar 1;85(4):836-44.
 

Jung SK, Lee KW, Byun S, Kang NJ, Lim SH, Heo YS, Bode AM, Bowden GT, Lee HJ, Dong Z. Myricetin suppresses UVB-induced skin cancer by targeting Fyn. Cancer Research. 2008 Jul 15;68(14):6021-9.